Original Articles

First-Line Endocrine Therapy Effectiveness in Recurrent HR+/HER2− Metastatic Breast Cancer: A Comprehensive Retrospective Study in Eastern Algeria. Asma BOUDERSA, Nassima KOUADRI, Taha FILALI. DOI: 10.48087/BJMS.2026.130601

A retrospective analysis of pediatric poisoning patterns and clinical outcomes in Algiers, Algeria. Mohamed BOULAHIA. DOI: 10.48087/BJMS.2026.130602

Surgical management of pelvic organ prolapse in Algiers: a retrospective descriptive single-center case series. Mohamed BOULAHIA. DOI: 10.48087/BJMS.2026.130603

Patient-Reported Unmet Palliative Care Needs as Indicators of Systemic Gaps in Cancer Care: a Tertiary Hospital Study in Guinea. Ibrahima Kalil CONDÉ, Mamady KEÏTA, Kalil CISSÉ, Abou CAMARA, Mamadou Bobo SOUARÉ, Malick BAH, Bangaly TRAORÉ. DOI: 10.48087/BJMS.2026.130604

Predictive factors of response to neoadjuvant chemotherapy in breast cancer: a single-centre retrospective  study of 71 patients. Adja Coumba DIALLO, Jaafar Ibn Abou Talib THIAM, Gorgui SARR, Amacoumba FALL, Ahmadou Bamba SEYE, Sidy KA. DOI: 10.48087/BJMS.2026.130605

Impact of the comprehensive medication management (CMM) approach on medication-related problems in hospitalized patients with diabetic foot ulcers at El Hadjar hospital (Annaba, Algeria): a prospective cohort study. Ikram AMAMRA, Abdekader DOUAOUI, Moufida GHARBI, Mehdi BELLEILI, Sihem ALI GUECHI, Adel GOURI. DOI: 10.48087/BJMS.2026.130606

Formulation and Stability Evaluation of a Pediatric Suspending Vehicle for Extemporaneous Compounding: Application to Furosemide. Mehdi BELLEILI, Adel GOURI, Youcef HADEF. DOI: 10.48087/BJMS.2026.130607

Epidemiological, clinical, and therapeutic characteristics of gallbladder cancer: a descriptive retrospective study. Ines BOUKERZAZA, Dalal ZERROUK, Taha FILALI. DOI: 10.48087/BJMS.2026.130608

Model-Informed Optimization of Amikacin Dosing in Renal Impairment According to KDIGO Classification Using Population Pharmacokinetic Modeling in Algeria. Fatima Zohra BOUAOUA, Karim BOULESBIAAT, Houari TOUMI, Pierre MARQUET, Moufida GHARBI, Hocine GACEM, Djamel MEKNASSI, Sabah BENBOUDIAF, Soumia BOUDJEMAA, Abd Elrahmanne ABDAOUI, Samira BOUKHARBACHE, Yacine KITOUNI, Soumia TIHAMI, Lamine GHANEM LAKHAL, Fatima FELOUAT, Imène SENHADJI. DOI: 10.48087/BJMS.2026.130609

Epidemiological profile of acute antihistamine poisonings recorded by the Poison Control Center of the Mohamed Lamine Debaghine University Hospital, Bab El Oued – Algeria (2020-2023). Chanez BOUMZAR, Lyna LAROUSSI, Salima ETTAIEB ERRAHMANI, Radia ZAMOUM, Salma KADDOUR. DOI: 10.48087/BJMS.2026.130610

Infections and Burns: experience of the Burn Unit of Batna. Fares Aissa BOUDIAF, Hanene BENALDJIA, Saïda ABOUBOU, Naoual BOUDOUH, Naoual BEGGARI, Nadia GRAINAT. DOI: 10.48087/BJMS.2026.130611

Amikacin and renal Impairment: optimized dosing regimens by pharmacokinetic simulation according to KDIGO Stages. Fatima Zohra BOUAOUA, Karim BOULESBIAAT, Houari TOUMI, Pierre MARQUET, Sihem ZITOUNI, Sabah BENBOUDIAF, Soumia BOUDJEMAA, Moufida GHARBI, Hocine GACEM, Haroune BOUAB, Nouar BOUDJOUREF, Nadia BOULEKHAL, Zoulikha BENHACINE, Zahra OUCHNENE, Zahia HAZMOUNE, Khaled BOUZENDA, Zakaria BOUREZAK, Abd El Jalil LALAOUNA, Mehdi GUEROUI, Nacer KHARNANE, Chaouki DERDOUS, Zahia BENABID, Linda AIMEUR, Malika LAMARA. DOI: 10.48087/BJMS.2026.130612

Predictors of severe postoperative hypocalcemia following parathyroid-ectomy for primary hyperparathyroidism: a retrospective cohort study. Mohamed Abderaouf KHALOUF, Nardjess SERIDJ, Leila RABEHI, Mohamed Lotfi BOUDJELLA, Djamila HAMOUDI, Abir LOUDDANI, Hassen RABEHI. DOI: 10.48087/BJMS.2026.130613

Ultrasound-guided central venous catheterization in intensive care: experience of the Essos Hospital Center (Yaoundé, Cameroon). Serge Vivier NGA NOMO, Aristide Gilles KUITCHET NJEUNJI, Cristella Raïssa IROUME BIFOUNA, Clovis KUETCHE, Serge ABOGO, Bonaventure JEMEA. DOI: 10.48087/BJMS.2026.130614

Review Articles

Targets of metabolic immunomodulators as possible therapeutic adjuncts for the management of pulmonary tuberculosis. Arinola GANIYU, Jimoh MUTIU, Adedeji OLAJUMOKE. DOI: 10.48087/BJMS.2026.130615

Advances in Viral Diagnostics: From Conventional Methods to Molecular and Genomic Technologies. Soran Qader ABDEL, Ahmed Farhan SHALLAL, Syamand Ahmed AHMED, Ibrahim Nazem QADER. DOI: 10.48087/BJMS.2026.130616

Vitiligo in a rheumatology context: Significance and therapeutic implications. Kamel REMITA. DOI: 10.48087/BJMS.2026.130617

Case Reports

Complete Pathological Response and Severe Hypothyroidism under Pembrolizumab in Triple-Negative Breast Cancer: Between Triumph and Toxicity – A Case Report. Asma BOUDERSA, Nassima KOUADRI, Hanene DJEDI. DOI: 10.48087/BJMS.2026.130618

Alport syndrome: a genetically confirmed x-linked case with early family screening. Sonia Yasmine KIRANE, Lahlou HADDAD, Wassila MESSADI, Amina SARI, Ourida GACEM. DOI: 10.48087/BJMS.2026.130619

Neurobrucellosis with demyelinating lesions and recurrent transient ischemic attacks in a young adult: a case report. Djamel CHEKRAR, Douniazed BADSI. DOI: 10.48087/BJMS.2026.130620

Management of an iatrogenic oro-sinus fistula using a pedicled fat pad flap from the cheek: a case report. Chahinez ABDELLAOUI, Amine MESLI, Kawter Fouzia BAROUDI. DOI: 10.48087/BJMS.2026.130621

When thrombosis reveals cancer: Trousseau’s syndrome as the initial manifestation of cholangiocarcinoma. Amine RAHOU, Saliha BOUKHEMACHA. DOI: 10.48087/BJMS.2026.130622

Spontaneous pneumomediastinum: a rare and serious complication of dermatomyositis. Saliha BOUKHEMACHA, Amine RAHOU. DOI: 10.48087/BJMS.2026.130623

Multifocal oral Kaposi sarcoma as inaugural manifestation of HIV infection: a clinical case report. Abdelkerim TAALLAH, Redouane MENDJEL. DOI: 10.48087/BJMS.2026.130624

Poikiloderma, a rare initial presentation of dermatomyositis. Lamia HASSANI. DOI: 10.48087/BJMS.2026.130625

Metaplastic breast carcinoma with osteoclast-like giant cells: a case report. Assia BENSALEM, Abdelaziz AMMARI. DOI: 10.48087/BJMS.2026.130626

Synchronous association of bilateral breast and prostate cancer in a male: a case report and literature review. Abdelaziz AMMARI, Meryem BOUDJERDA, Sihem BENSALEM, Assia BENSALEM. DOI: 10.48087/BJMS.2026.130627

Primary neuroendocrine tumor of the kidney: an exceptional entity illustrated by a case report. Sihem BENSALEM, Amina KHODJA, Abdelaziz AMMARI, Assia BENSALEM. DOI: 10.48087/BJMS.2026.130628

Metastatic intra-abdominal paraganglioma revealed by gastrointestinal bleeding: a case report. Sihem BENSALEM, Amina KHODJA, Abdelaziz AMMARI, Assia BENSALEM. DOI: 10.48087/BJMS.2026.130629

Gastric schwannoma: a case report. Youcef KHENCHOUL. DOI: 10.48087/BJMS.2026.130630

A severe case of Mediterranean spotted fever. Nabila CHOUBANE. DOI: 10.48087/BJMS.2026.130631

Pancreatic cancer associated with gallbladder malignancy: coincidence or common genetic pathway?. Raouf MENOURA, Walid TIBERMACINE, Sorya BELKHIRI, Ratiba ACHOURI, Fateh HAMMOUDI, Sana TACHOUR, Bouchera RAIS, Abd elhak DELMI. DOI: 10.48087/BJMS.2026.130632

Evaluation of the neurovascular pathway: The value of specialized training in reducing in-hospital stays and increasing IV thrombolysis rates. Experience of the neurovascular unit at EHU Oran from 2015 to 2024. Douniazede BADSI, Khadidja TERKI, Djawed SAYEH, Djamel CHAKRAR. DOI: 10.48087/BJMS.2026.130501

Well-Differentiated Grade 3 Gastric Neuroendocrine Tumors: Diagnostic Challenges and Therapeutic Perspectives. Zakia KASSAMA, Dalal ZERROUK, Souad HAMDOUCHE. Hichem Elazhari BENMAMAR. Mohamed Nour CHEHAD. DOI: 10.48087/BJMS.2026.130502

Pes Cavus and the domino effect on the musculoskeletal system: Clinical implications across the kinetic chain from foot to spine. Kamel REMITA, Mohamed Hassan AL FAHEL, Wissem Soumia HADDAD. DOI: 10.48087/BJMS.2026.130503

Complete Androgen Insensitivity Syndrome (CAIS): the contribution of imaging to diagnosis and management, illustrated by a clinical case and a review of the literature. Hichem El Azhari BENMAMAR, Youcef KHENCHOUL, Mustapha BOUMENDJEL, Dalal  ZERROUK. DOI: 10.48087/BJMS.2026.130504

HIV seroprevalence and acceptability of antenatal screening among pregnant women in urban and semi‑urban areas of Eastern Algeria. Zahira BOUDIAF, Sabiha BOUZBID, Nassima DJAHMI, Hayet AOURES, Naima MESSALHI, Nadia TIGHA, Amel TOUAREF, Sabrina NEDJAI, Mekki AIDAOUI, Amine MAMMERI. DOI: 10.48087/BJMS.2026.130505

Thrombolysis during Cardiopulmonary Resuscitation in Cardiac Arrest Secondary to Acute Coronary Syndrome: Four-Case Series. Fadela AOUNE, Fouzia BELABES, Nesrine TEBIB, Amina KHOULKHLAL, Afaf BENKHEMKHEM. DOI: 10.48087/BJMS.2026.130506

Epidemiological and prognostic profiles of patients admitted for brain injuries in medical-surgical emergency intensive care: a retrospective study at Mostaganem University Hospital. Fadela AOUNE, Fouzia BELABES, Nesrine TEBIBB, Amina KHOULKHLAL, Afaf BENKHEMKHEM, Yasin OBAIDA, Ibrahim ABUARRA, Ikram BERREZOUG. DOI: 10.48087/BJMS.2026.130507

Severe Anaphylactic Shock Induced by Intravenous Ketamine during Anesthesia: A Case Report Confirmed by Allergy Testing. Fadela AOUNE, Fouzia BELABES, Nesrine TEBIBB, Amina KHOULKHLAL, Afaf BENKHEMKHEM, Zakaria MESSABIHI. DOI: 10.48087/BJMS.2026.130508

Comparison of all-on-4 and all-on-6 techniques in implant-supported rehabilitation: scientific analysis of the literature. Hakima HOUARI BELKADI, Linda AMROUN, Fatima Zohra HOUARI, Ali BOUHEKA, Chourouk BENCHAA, Nadia BENKHOUDA, Chahra BENDOUMA, Abd-Elkader CHORFI. DOI: 10.48087/BJMS.2026.130509

Metastatic Spread of Medulloblastoma in Pediatric Patients. Sandra FEKNOUS, Malika LOUANCHI, Mourad BOUAZIZ. DOI: 10.48087/BJMS.2026.130510

Atypical teratoid rhabdoid tumor of the posterior fossa in a child. A case report. Sandra FEKNOUS, Malika LOUANCHI, Marouane Fateh AMARA KORBA, Abdelkrim MANSOUR, Mourad BOUAZIZ. DOI: 10.48087/BJMS.2026.130511

Successive Development of Three Histologically Distinct Primary Malignancies: Synovialosarcoma, Colorectal Adenocarcinoma, and Pulmonary Large Cell Neuroendocrine Carcinoma. A Case Report. Abdelaziz AMMARI, Assia BENSALEM, Sihem BENSALEM, Madjda LADOUALI. DOI: 10.48087/BJMS.2026.130512

Real-World Efficacy and Safety of the KEYNOTE-522 Protocol for Neoadjuvant Triple-Negative Breast Cancer: A Single-Center Experience. Assia BENSALEM, Khouloud BRAHIMI, Abdelaziz AMMARI, Sihem BENSALEM, Nour Djihane BOUATROUS, Meryem BOUDJERDA. DOI: 10.48087/BJMS.2026.130513

From qPCR to Next-Generation Sequencing: Practical Strategies for Resource-Limited Molecular Laboratories. Imène BENAMIRA, Zouhir DJENNA, Louisa BECHOHRA. DOI: 10.48087/BJMS.2026.130514

Musculoskeletal involvement of the wrists and hands in Systemic Lupus Erythematosus: A narrative review. Naoual KHALDOUN, Soumia LOUAHCHI, Aicha LADJOUZE, Fella HANNI. DOI: 10.48087/BJMS.2026.130515

Co-infections and Acute Disseminated Encephalomyelitis: A Case Report of a Child in Batna, Algeria. Nora RIGHI, Loubna RAHMOUNE, Melissa DOUMANDJI, Samy SLIMANI, Chantal SOBACE, Yahia MEKKI, Daniel FLORET, Bruno LINA. DOI: 10.48087/BJMS.2026.130516

Rare Pediatric Meningoencephalitis Due to Streptococcus pneumoniae and Enterovirus Co-Infection: A Case Report and Review. Nora RIGHI, Samia KATOUCHE, Melissa DOUMANDJI, Meriem DEBBABI, Samy SLIMANI, Bruno LINA. DOI: 10.48087/BJMS.2026.130517

Original Articles / Articles originaux

Contribution to the knowledge of local fungal biodiversity: inventory of macromycetes in three regions of eastern Algeria. Khatima MEZHOUD, El Amine CHEROUAL, Imene BOUFENARA, Manar BOUHEDJA, Wail BOUDRAA. DOI: 10.48087/BJMS.2026.130401

Hemostasis disorders predisposing to portal vein thrombosis. Mohammed Nazim BENNAOUM, Abdelmadjid MEGUEDAD, Affaf ADDA, Chafika MANOUNI, Mohamed CHEKKAL. DOI: 10.48087/BJMS.2026.130402

Treatment of obstructive colon cancer, a comparative study between one-stage and two-stage treatments. Zoheir BOUCHAIR, Khalida CHARAOUI, Amira BELHAMRA, Mohamed BENTAMENE, Imene NEHAL, Rabeh KHENNAOUI, Ali BELMIR. DOI: 10.48087/BJMS.2026.130403

Survey of Dentists’ Knowledge Regarding Medication-Related Osteonecrosis of the Jaws. Meriem TAGUIA, Razika SALAH MARS. DOI: 10.48087/BJMS.2026.130404

Impact of implementing patient procedures on perioperative safety  adherence in digestive oncological surgery. Farida ILIMI, Amel Leila REBOUH, Hamida GUENDOUZ, Lyès RAHAL. DOI: 10.48087/BJMS.2026.130405

Primary cardiac Sarcomas: A clinic pathological Study of Seven Cases. Hanifa BENALIKHOUDJA, Sofiane GHEMRI, Nawel  DJOUDI. DOI: 10.48087/BJMS.2026.130406

Mortality among burn patients: experience of the burn unit of Batna university hospital. Fares Aissa BOUDIAF, Saida ABOUBOU, Naoual BOUDOUH, Naoual BEGGARI, Nadia GRAINAT. DOI: 10.48087/BJMS.2026.130407

Population pharmacokinetics of amikacin in Algeria: implications for dosing optimization and individualized therapy. Fatima Zohra BOUAOUA, Houari TOUMI, Karim BOULESBIAAT,Habiba FETATI, Hocine GACEM, Farida BOUCHNAK, Abdelrahmane ABDAOUI, Zahia HAZMOUNE, Badis FOUGHALI, Soumia BOUDJEMAA, Sabah BENBOUDIAF, Fatma Zohra BOUDIA, Rafika LAICHE, Faiza BOUCHALA, Kamel MANSOURI. DOI: 10.48087/BJMS.2026.130408

Equimolar mixture of oxygen and nitrous oxide as a method of conscious sedation in dentistry: a systematic literature review. Fouzia Kawter BAROUDI, Nawel ALLAL, Fouad OUDGHIRI, Amina KEDDAR, Chahinez ABDELAOUI. DOI: 10.48087/BJMS.2026.130409

Review Articles / Mise au point

VEXAS syndrome : literature review. Abdelhak ABABSA MOUAKI, Ouassila ABBASI. DOI: 10.48087/BJMS.2026.130410

Case reports / Cas cliniques

Acute intestinal occlusion revealing a left paraduodenal hernia: case report. Louiza IAICHE ACHOUR, Zakaria SEOUDI, Sara MEHENNI, Razika IBAGRACHE, Mohamed ALES, Abdelkrim ANOU. DOI: 10.48087/BJMS.2026.130411

Early-onset peripheral sensorimotor neuropathy associated with systemic lupus erythematosus: a case report. Ayoub REMILAOUI, Hadjer CHIBA, Farida MECHID-HADJARAB, Chafia DAHOU-MAKHLOUFI. DOI: 10.48087/BJMS.2026.130412

Small bowel hemangioma: a remarkable clinical case. Zakaria SEOUDI, Mohamed STOUTAH, Louiza IAICHE ACHOUR, Farouk BAKHTI, Samia ARAB, Nour El-Imane DJEBBAR, Abdelkrim ANOU. DOI: 10.48087/BJMS.2026.130413

Late Replantation (24 Hours) of an Avulsed Immature Maxillary Central Incisor in a Child: Biological Challenges and Therapeutic Considerations – A Case Report. Amel Rania BENYOUB, Nawel ALLAL, Fouad OUDGHIRI, Amina KEDDAR, Houda BENTURQUIA, Mohammed Zakarya KECHEKOUCH. DOI: 10.48087/BJMS.2026.130414

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130414

Authors: Amel Rania BENYOUB, Nawel ALLAL, Fouad OUDGHIRI, Amina KEDDAR, Houda BENTURQUIA, Mohammed Zakarya KECHEKOUCH

Affiliations: Service d’odontologie conservatrice et endodontie, CHU Tlemcen – Algérie.

Abstract

Tooth avulsion is a dental emergency whose prognosis depends on extra-oral time and the choice of storage medium. This case report describes a 10-year-old boy who presented 24 hours after avulsion of tooth 21, which had been stored dry in the interim. Despite a delay far exceeding the IADT 2020 guidelines, replantation was attempted in order to preserve aesthetics and alveolar bone. The protocol included atraumatic replantation, flexible splinting, and antibiotic therapy. Follow-up was, however, complicated by the patient’s repeated absences from recall appointments, which contributed to the early onset of inflammatory root resorption. Rigorous endodontic disinfection combined with MTA apexification successfully stabilized the tooth. At one-year follow-up, the tooth remains functional with preserved alveolar bone. This case underscores the critical role of patient cooperation in the long-term success of late replantations.

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Keywords:dental avulsion, late replantation, immature tooth, apexification, dental trauma.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130413

Authors: Zakaria SEOUDI¹, Mohamed STOUTAH¹, Louiza IAICHE ACHOUR¹, Farouk BAKHTI¹, Samia ARAB², Nour El-Imane DJEBBAR³, Abdelkrim ANOU¹

Affiliations: 1- Department of General, Oncologic & Emergency Surgery. Douera University Hospital. Faculty of Medicine. Blida 1 University. Algeria. 2- Department of Anesthesiology, Resuscitation & Intensive Medicine. Douera University Hospital. Blida1 University. Algeria. 3- Department of Pathology. Douera University Hospital. Faculty of Medicine. Blida 1 University. Algeria.

Abstract

Gastrointestinal hemangiomas are benign, generally rare lesions with a predilection for the small intestine. Due to their rarity, they can easily go undetected in clinical practice. Diagnosing small bowel hemangiomas can be challenging, particularly given their wide range of clinical presentations that may mimic other conditions. While imaging is essential for diagnosis and treatment planning, it can also be a source of pitfalls, leading to confusion and misdiagnosis — most notably, erroneous classification as a malignant tumor, thereby complicating accurate preoperative diagnosis. We present here the case of a 58-year-old woman with a small bowel mass manifesting as abdominal pain, initially misdiagnosed as a tumor on imaging. This unusual case illustrates the difficulty of identifying a hemangioma preoperatively; the definitive diagnosis was ultimately established by histopathological examination following segmental intestinal resection. Through this case report, we aim to provide clinicians with practical insights to better recognize this rare pathology and to consider it in the differential diagnosis of small bowel tumors.

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Keywords: hemangioma,  small intestine, case report.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130412

Authors: Ayoub REMILAOUI¹, Hadjer CHIBA¹˒², Farida MECHID-HADJARAB¹˒², Chafia DAHOU-MAKHLOUFI¹˒²

Affiliations: 1- Department of Rheumatology, Bab El Oued University Hospital Center, Algiers, Algeria. 2- Faculty of Medicine, Youcef El Khatib University of Health Sciences, Algiers, Algeria.

Abstract

Background: Peripheral neuropathy is an uncommon but potentially disabling manifestation of systemic lupus erythematosus (SLE), particularly when it occurs early in the disease course. Its clinical and electrophysiological heterogeneity often makes diagnosis challenging. Case Presentation: We report the case of a 21-year-old man presenting with inflammatory arthralgia followed by progressive sensorimotor peripheral neuropathy predominantly affecting the lower limbs. Electroneuromyography revealed a diffuse sensorimotor polyneuropathy with severe axonal involvement and demyelinating features. Immunological investigations showed high-titer antinuclear antibodies, positive anti-double-stranded DNA and anti-nucleosome antibodies, and normal complement levels. A structured diagnostic work-up excluded alternative metabolic, infectious, toxic, and drug-related etiologies. The diagnosis of active SLE was established according to the 2019 ACR/EULAR classification criteria. Treatment with high-dose corticosteroids, hydroxychloroquine, and immunosuppressive therapy resulted in progressive clinical and electrophysiological improvement. Conclusion: This case highlights that peripheral sensorimotor neuropathy may represent an early manifestation of SLE. Early recognition and individualized immunosuppressive management are essential to improve neurological outcomes and limit long-term disability.

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Keywords: systemic lupus erythematosus, peripheral neuropathy, neuropsychiatric lupus, sensorimotor neuropathy, immunosuppressive therapy.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130411

Authors: Louiza IAICHE ACHOUR¹, Zakaria SEOUDI¹, Sara MEHENNI¹, Razika IBAGRACHE¹, Mohamed ALES¹, Abdelkrim ANOU¹

Affiliations: Faculty of Medicine. University Saad Dahleb Blida 1. Department of visceral and digestive surgery Douera Hospital – Algeria

Abstract

Internal hernias are relatively rare, accounting for less than 1% of all abdominal hernias, with paraduodenal hernia being the most common subtype. Left paraduodenal hernia is a particularly rare condition that may constitute a surgical emergency. Its diagnosis is challenging due to its nonspecific clinical presentation and the wide variety of possible symptoms, necessitating careful and close monitoring. Intestinal obstruction is an uncommon presenting complaint. Computed tomography remains the gold standard for definitive diagnosis. Surgical repair, whether via an open or laparoscopic approach, is currently the preferred therapeutic option. We report a case of left paraduodenal hernia diagnosed in the context of intestinal obstruction in a 27-year-old patient managed in our surgical department.

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Keywords: internal hernia, left paraduodenal hernia, acute intestinal obstruction.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130410

Authors: Abdelhak ABABSA MOUAKI, Ouassila ABBASI

Affiliations: Service de médecine interne EHS Athmana Mahmoud, Batna – Algérie

Abstract

VEXAS is an acronym standing for vacuoles, enzyme E1, X-linked, autoinflammatory, and somatic. It designates an autoinflammatory syndrome in adults, first described in 2020, linked to acquired somatic mutations in the UBA1 gene (ubiquitin-activating enzyme E1), located on the X chromosome and restricted to the hematopoietic compartment. The syndrome primarily affects men over 50 years of age, combining systemic inflammatory manifestations with suggestive hematological abnormalities. VEXAS syndrome should be considered in male patients presenting with incomplete or complete features of relapsing polychondritis, polyarteritis nodosa, giant cell arteritis, or Sweet’s syndrome — particularly when refractory to treatment and associated with hematological involvement such as cytopenias, myelodysplastic syndrome, or thromboembolic disease. Diagnosis relies on the identification of pathogenic variants of UBA1 — primarily p.Met41 — in blood or bone marrow. Management remains poorly defined and is based on two complementary approaches: anti-inflammatory treatment (corticosteroids, tocilizumab, JAK inhibitors) and/or targeting of the mutated hematopoietic clone (azacitidine, allogeneic hematopoietic stem cell transplantation), combined with appropriate supportive care.

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Keywords: VEXAS syndrome, UBA1, Myelodysplastic syndrome, Autoinflammatory diseases.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130409

Authors: Fouzia Kawter BAROUDI, Nawel ALLAL, Fouad OUDGHIRI, Amina KEDDAR, Chahinez ABDELAOUI

Affiliations: Department of Dental Medicine, CHU Tlemcen, Algeria

Abstract

Background: The equimolar mixture of oxygen and nitrous oxide (MEOPA) is widely used for conscious sedation in dentistry. It facilitates the management of anxious or uncooperative patients and represents an alternative to general anesthesia. Objective: To evaluate the effectiveness, safety, and clinical indications of MEOPA in improving the management of difficult patients and optimizing treatment outcomes. Methods: A systematic review was conducted in accordance with PRISMA 2020 guidelines. An electronic search was performed in the PubMed and Lissa databases, covering English- and French-language publications from 2004 to 2024. Studies were selected based on predefined inclusion and exclusion criteria following the screening of titles, abstracts, and full texts. Results: The search identified 31 articles, of which 9 were included in the final analysis. Findings indicate that MEOPA significantly improves patient cooperation, reduces anxiety, and facilitates dental care delivery. Its combination with midazolam further enhances its effectiveness. MEOPA is particularly beneficial for patients with intellectual disabilities and during tooth extractions. Adverse effects, such as vomiting, are rare (< 1%) and are generally associated with the duration or depth of sedation. The use of the Porter/Brown mask additionally reduces nitrous oxide emissions, promoting a more environmentally responsible practice. Conclusions: MEOPA is an effective and safe sedation technique in dentistry, optimizing the management of difficult patients and enhancing the overall dental care experience. However, the heterogeneity across the included studies underscores the need for further standardized research.

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Keywords: MEOPA, Nitrous Oxide, Conscious Sedation, Dental Care, Dental Anxiety, Pediatric Dentistry.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130408

Authors: Fatima Zohra BOUAOUA¹, Houari TOUMI², Karim BOULESBIAAT³,Habiba FETATI², Hocine GACEM³, Farida BOUCHNAK⁴, Abdelrahmane ABDAOUI², Zahia HAZMOUNE¹, Badis FOUGHALI¹, Soumia BOUDJEMAA³, Sabah BENBOUDIAF¹, Fatma Zohra BOUDIA², Rafika LAICHE³, Faiza BOUCHALA⁵, Kamel MANSOURI⁴

Affiliations: 1- Faculté de médecine, Université Constantine 3 – Salah Boubnider, Algérie. 2- Faculté de médecine, Université d’Oran 1 Ahmed Ben Bella, Algérie. 3- Faculté de médecine, Université de Batna 2 – Mostefa Ben Boulaïd, Algérie. 4- Faculté de médecine, Université d’Alger 1 Benyoucef Benkhedda, Algérie. 5- Faculté de médecine, Université Ferhat Abbas Sétif 1, Algérie.

Abstract

Introduction: Amikacin is a bactericidal aminoglycoside widely used in the treatment of severe infections caused by multidrug-resistant Gram-negative bacilli. Its clinical use is limited by significant interindividual pharmacokinetic variability and the risk of nephrotoxicity and ototoxicity. Its narrow therapeutic window complicates dose individualization, making it challenging to optimize efficacy while minimizing toxicity. The objective of this study was to develop an initial dose adjustment approach for amikacin based on a population pharmacokinetic (PKpop) model integrated with therapeutic drug monitoring (TDM), in order to propose optimized dosing regimens. Materials and Methods: A retrospective and prospective study was conducted in hospitalized patients receiving amikacin. Plasma concentrations were measured using an immunoenzymatic method and modeled using a nonlinear mixed-effects approach. Covariates assessed included body weight and creatinine clearance. Monte Carlo simulations were performed on 1,000 virtual patients to evaluate the probability of target attainment for minimum (Cmin) and maximum (Cmax) plasma concentrations. Results: Among the 50 patients with normal renal function included (MDRD: 115.8 ± 13 mL/min), a one-compartment model was selected, estimating a population volume of distribution (Vpop) of 23.3 L, 70.8 L, and 21.5 L, and a population clearance (Clpop) of 2.4 L/h, 6.5 L/h, and 2.7 L/h for children, adults, and elderly patients, respectively. Relative standard errors were low, indicating good model precision and stability. Simulations demonstrated that optimal doses to achieve target concentrations varied by age group: 50 mg/kg every 24 hours for adults, and 20 mg/kg every 36–48 hours for children and elderly patients. Discussion: These findings suggest that standard dosing regimens are often insufficient to meet efficacy and safety targets. Integrating population pharmacokinetics with therapeutic drug monitoring enables dose individualization, improves treatment efficacy, and reduces the risk of toxicity.

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Keywords: Amikacin, population pharmacokinetics, therapeutic drug monitoring, simulation.