Original Articles / Articles originaux

Contribution to the knowledge of local fungal biodiversity: inventory of macromycetes in three regions of eastern Algeria. Khatima MEZHOUD, El Amine CHEROUAL, Imene BOUFENARA, Manar BOUHEDJA, Wail BOUDRAA. DOI: 10.48087/BJMS.2026.130401

Hemostasis disorders predisposing to portal vein thrombosis. Mohammed Nazim BENNAOUM, Abdelmadjid MEGUEDAD, Affaf ADDA, Chafika MANOUNI, Mohamed CHEKKAL. DOI: 10.48087/BJMS.2026.130402

Treatment of obstructive colon cancer, a comparative study between one-stage and two-stage treatments. Zoheir BOUCHAIR, Khalida CHARAOUI, Amira BELHAMRA, Mohamed BENTAMENE, Imene NEHAL, Rabeh KHENNAOUI, Ali BELMIR. DOI: 10.48087/BJMS.2026.130403

Survey of Dentists’ Knowledge Regarding Medication-Related Osteonecrosis of the Jaws. Meriem TAGUIA, Razika SALAH MARS. DOI: 10.48087/BJMS.2026.130404

Impact of implementing patient procedures on perioperative safety  adherence in digestive oncological surgery. Farida ILIMI, Amel Leila REBOUH, Hamida GUENDOUZ, Lyès RAHAL. DOI: 10.48087/BJMS.2026.130405

Primary cardiac Sarcomas: A clinic pathological Study of Seven Cases. Hanifa BENALIKHOUDJA, Sofiane GHEMRI, Nawel  DJOUDI. DOI: 10.48087/BJMS.2026.130406

Mortality among burn patients: experience of the burn unit of Batna university hospital. Fares Aissa BOUDIAF, Saida ABOUBOU, Naoual BOUDOUH, Naoual BEGGARI, Nadia GRAINAT. DOI: 10.48087/BJMS.2026.130407

Population pharmacokinetics of amikacin in Algeria: implications for dosing optimization and individualized therapy. Fatima Zohra BOUAOUA, Houari TOUMI, Karim BOULESBIAAT,Habiba FETATI, Hocine GACEM, Farida BOUCHNAK, Abdelrahmane ABDAOUI, Zahia HAZMOUNE, Badis FOUGHALI, Soumia BOUDJEMAA, Sabah BENBOUDIAF, Fatma Zohra BOUDIA, Rafika LAICHE, Faiza BOUCHALA, Kamel MANSOURI. DOI: 10.48087/BJMS.2026.130408

Equimolar mixture of oxygen and nitrous oxide as a method of conscious sedation in dentistry: a systematic literature review. Fouzia Kawter BAROUDI, Nawel ALLAL, Fouad OUDGHIRI, Amina KEDDAR, Chahinez ABDELAOUI. DOI: 10.48087/BJMS.2026.130409

Review Articles / Mise au point

VEXAS syndrome : literature review. Abdelhak ABABSA MOUAKI, Ouassila ABBASI. DOI: 10.48087/BJMS.2026.130410

Case reports / Cas cliniques

Acute intestinal occlusion revealing a left paraduodenal hernia: case report. Louiza IAICHE ACHOUR, Zakaria SEOUDI, Sara MEHENNI, Razika IBAGRACHE, Mohamed ALES, Abdelkrim ANOU. DOI: 10.48087/BJMS.2026.130411

Early-onset peripheral sensorimotor neuropathy associated with systemic lupus erythematosus: a case report. Ayoub REMILAOUI, Hadjer CHIBA, Farida MECHID-HADJARAB, Chafia DAHOU-MAKHLOUFI. DOI: 10.48087/BJMS.2026.130412

Small bowel hemangioma: a remarkable clinical case. Zakaria SEOUDI, Mohamed STOUTAH, Louiza IAICHE ACHOUR, Farouk BAKHTI, Samia ARAB, Nour El-Imane DJEBBAR, Abdelkrim ANOU. DOI: 10.48087/BJMS.2026.130413

Late Replantation (24 Hours) of an Avulsed Immature Maxillary Central Incisor in a Child: Biological Challenges and Therapeutic Considerations – A Case Report. Amel Rania BENYOUB, Nawel ALLAL, Fouad OUDGHIRI, Amina KEDDAR, Houda BENTURQUIA, Mohammed Zakarya KECHEKOUCH. DOI: 10.48087/BJMS.2026.130414

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DOI: 10.48087/BJMS.2026.130414

Authors: Amel Rania BENYOUB, Nawel ALLAL, Fouad OUDGHIRI, Amina KEDDAR, Houda BENTURQUIA, Mohammed Zakarya KECHEKOUCH

Affiliations: Service d’odontologie conservatrice et endodontie, CHU Tlemcen – Algérie.

Abstract

Tooth avulsion is a dental emergency whose prognosis depends on extra-oral time and the choice of storage medium. This case report describes a 10-year-old boy who presented 24 hours after avulsion of tooth 21, which had been stored dry in the interim. Despite a delay far exceeding the IADT 2020 guidelines, replantation was attempted in order to preserve aesthetics and alveolar bone. The protocol included atraumatic replantation, flexible splinting, and antibiotic therapy. Follow-up was, however, complicated by the patient’s repeated absences from recall appointments, which contributed to the early onset of inflammatory root resorption. Rigorous endodontic disinfection combined with MTA apexification successfully stabilized the tooth. At one-year follow-up, the tooth remains functional with preserved alveolar bone. This case underscores the critical role of patient cooperation in the long-term success of late replantations.

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Keywords:dental avulsion, late replantation, immature tooth, apexification, dental trauma.

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DOI: 10.48087/BJMS.2026.130413

Authors: Zakaria SEOUDI¹, Mohamed STOUTAH¹, Louiza IAICHE ACHOUR¹, Farouk BAKHTI¹, Samia ARAB², Nour El-Imane DJEBBAR³, Abdelkrim ANOU¹

Affiliations: 1- Department of General, Oncologic & Emergency Surgery. Douera University Hospital. Faculty of Medicine. Blida 1 University. Algeria. 2- Department of Anesthesiology, Resuscitation & Intensive Medicine. Douera University Hospital. Blida1 University. Algeria. 3- Department of Pathology. Douera University Hospital. Faculty of Medicine. Blida 1 University. Algeria.

Abstract

Gastrointestinal hemangiomas are benign, generally rare lesions with a predilection for the small intestine. Due to their rarity, they can easily go undetected in clinical practice. Diagnosing small bowel hemangiomas can be challenging, particularly given their wide range of clinical presentations that may mimic other conditions. While imaging is essential for diagnosis and treatment planning, it can also be a source of pitfalls, leading to confusion and misdiagnosis — most notably, erroneous classification as a malignant tumor, thereby complicating accurate preoperative diagnosis. We present here the case of a 58-year-old woman with a small bowel mass manifesting as abdominal pain, initially misdiagnosed as a tumor on imaging. This unusual case illustrates the difficulty of identifying a hemangioma preoperatively; the definitive diagnosis was ultimately established by histopathological examination following segmental intestinal resection. Through this case report, we aim to provide clinicians with practical insights to better recognize this rare pathology and to consider it in the differential diagnosis of small bowel tumors.

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Keywords: hemangioma,  small intestine, case report.

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DOI: 10.48087/BJMS.2026.130412

Authors: Ayoub REMILAOUI¹, Hadjer CHIBA¹˒², Farida MECHID-HADJARAB¹˒², Chafia DAHOU-MAKHLOUFI¹˒²

Affiliations: 1- Department of Rheumatology, Bab El Oued University Hospital Center, Algiers, Algeria. 2- Faculty of Medicine, Youcef El Khatib University of Health Sciences, Algiers, Algeria.

Abstract

Background: Peripheral neuropathy is an uncommon but potentially disabling manifestation of systemic lupus erythematosus (SLE), particularly when it occurs early in the disease course. Its clinical and electrophysiological heterogeneity often makes diagnosis challenging. Case Presentation: We report the case of a 21-year-old man presenting with inflammatory arthralgia followed by progressive sensorimotor peripheral neuropathy predominantly affecting the lower limbs. Electroneuromyography revealed a diffuse sensorimotor polyneuropathy with severe axonal involvement and demyelinating features. Immunological investigations showed high-titer antinuclear antibodies, positive anti-double-stranded DNA and anti-nucleosome antibodies, and normal complement levels. A structured diagnostic work-up excluded alternative metabolic, infectious, toxic, and drug-related etiologies. The diagnosis of active SLE was established according to the 2019 ACR/EULAR classification criteria. Treatment with high-dose corticosteroids, hydroxychloroquine, and immunosuppressive therapy resulted in progressive clinical and electrophysiological improvement. Conclusion: This case highlights that peripheral sensorimotor neuropathy may represent an early manifestation of SLE. Early recognition and individualized immunosuppressive management are essential to improve neurological outcomes and limit long-term disability.

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Keywords: systemic lupus erythematosus, peripheral neuropathy, neuropsychiatric lupus, sensorimotor neuropathy, immunosuppressive therapy.

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DOI: 10.48087/BJMS.2026.130411

Authors: Louiza IAICHE ACHOUR¹, Zakaria SEOUDI¹, Sara MEHENNI¹, Razika IBAGRACHE¹, Mohamed ALES¹, Abdelkrim ANOU¹

Affiliations: Faculty of Medicine. University Saad Dahleb Blida 1. Department of visceral and digestive surgery Douera Hospital – Algeria

Abstract

Internal hernias are relatively rare, accounting for less than 1% of all abdominal hernias, with paraduodenal hernia being the most common subtype. Left paraduodenal hernia is a particularly rare condition that may constitute a surgical emergency. Its diagnosis is challenging due to its nonspecific clinical presentation and the wide variety of possible symptoms, necessitating careful and close monitoring. Intestinal obstruction is an uncommon presenting complaint. Computed tomography remains the gold standard for definitive diagnosis. Surgical repair, whether via an open or laparoscopic approach, is currently the preferred therapeutic option. We report a case of left paraduodenal hernia diagnosed in the context of intestinal obstruction in a 27-year-old patient managed in our surgical department.

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Keywords: internal hernia, left paraduodenal hernia, acute intestinal obstruction.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130410

Authors: Abdelhak ABABSA MOUAKI, Ouassila ABBASI

Affiliations: Service de médecine interne EHS Athmana Mahmoud, Batna – Algérie

Abstract

VEXAS is an acronym standing for vacuoles, enzyme E1, X-linked, autoinflammatory, and somatic. It designates an autoinflammatory syndrome in adults, first described in 2020, linked to acquired somatic mutations in the UBA1 gene (ubiquitin-activating enzyme E1), located on the X chromosome and restricted to the hematopoietic compartment. The syndrome primarily affects men over 50 years of age, combining systemic inflammatory manifestations with suggestive hematological abnormalities. VEXAS syndrome should be considered in male patients presenting with incomplete or complete features of relapsing polychondritis, polyarteritis nodosa, giant cell arteritis, or Sweet’s syndrome — particularly when refractory to treatment and associated with hematological involvement such as cytopenias, myelodysplastic syndrome, or thromboembolic disease. Diagnosis relies on the identification of pathogenic variants of UBA1 — primarily p.Met41 — in blood or bone marrow. Management remains poorly defined and is based on two complementary approaches: anti-inflammatory treatment (corticosteroids, tocilizumab, JAK inhibitors) and/or targeting of the mutated hematopoietic clone (azacitidine, allogeneic hematopoietic stem cell transplantation), combined with appropriate supportive care.

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Keywords: VEXAS syndrome, UBA1, Myelodysplastic syndrome, Autoinflammatory diseases.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130409

Authors: Fouzia Kawter BAROUDI, Nawel ALLAL, Fouad OUDGHIRI, Amina KEDDAR, Chahinez ABDELAOUI

Affiliations: Department of Dental Medicine, CHU Tlemcen, Algeria

Abstract

Background: The equimolar mixture of oxygen and nitrous oxide (MEOPA) is widely used for conscious sedation in dentistry. It facilitates the management of anxious or uncooperative patients and represents an alternative to general anesthesia. Objective: To evaluate the effectiveness, safety, and clinical indications of MEOPA in improving the management of difficult patients and optimizing treatment outcomes. Methods: A systematic review was conducted in accordance with PRISMA 2020 guidelines. An electronic search was performed in the PubMed and Lissa databases, covering English- and French-language publications from 2004 to 2024. Studies were selected based on predefined inclusion and exclusion criteria following the screening of titles, abstracts, and full texts. Results: The search identified 31 articles, of which 9 were included in the final analysis. Findings indicate that MEOPA significantly improves patient cooperation, reduces anxiety, and facilitates dental care delivery. Its combination with midazolam further enhances its effectiveness. MEOPA is particularly beneficial for patients with intellectual disabilities and during tooth extractions. Adverse effects, such as vomiting, are rare (< 1%) and are generally associated with the duration or depth of sedation. The use of the Porter/Brown mask additionally reduces nitrous oxide emissions, promoting a more environmentally responsible practice. Conclusions: MEOPA is an effective and safe sedation technique in dentistry, optimizing the management of difficult patients and enhancing the overall dental care experience. However, the heterogeneity across the included studies underscores the need for further standardized research.

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Keywords: MEOPA, Nitrous Oxide, Conscious Sedation, Dental Care, Dental Anxiety, Pediatric Dentistry.

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DOI: 10.48087/BJMS.2026.130408

Authors: Fatima Zohra BOUAOUA¹, Houari TOUMI², Karim BOULESBIAAT³,Habiba FETATI², Hocine GACEM³, Farida BOUCHNAK⁴, Abdelrahmane ABDAOUI², Zahia HAZMOUNE¹, Badis FOUGHALI¹, Soumia BOUDJEMAA³, Sabah BENBOUDIAF¹, Fatma Zohra BOUDIA², Rafika LAICHE³, Faiza BOUCHALA⁵, Kamel MANSOURI⁴

Affiliations: 1- Faculté de médecine, Université Constantine 3 – Salah Boubnider, Algérie. 2- Faculté de médecine, Université d’Oran 1 Ahmed Ben Bella, Algérie. 3- Faculté de médecine, Université de Batna 2 – Mostefa Ben Boulaïd, Algérie. 4- Faculté de médecine, Université d’Alger 1 Benyoucef Benkhedda, Algérie. 5- Faculté de médecine, Université Ferhat Abbas Sétif 1, Algérie.

Abstract

Introduction: Amikacin is a bactericidal aminoglycoside widely used in the treatment of severe infections caused by multidrug-resistant Gram-negative bacilli. Its clinical use is limited by significant interindividual pharmacokinetic variability and the risk of nephrotoxicity and ototoxicity. Its narrow therapeutic window complicates dose individualization, making it challenging to optimize efficacy while minimizing toxicity. The objective of this study was to develop an initial dose adjustment approach for amikacin based on a population pharmacokinetic (PKpop) model integrated with therapeutic drug monitoring (TDM), in order to propose optimized dosing regimens. Materials and Methods: A retrospective and prospective study was conducted in hospitalized patients receiving amikacin. Plasma concentrations were measured using an immunoenzymatic method and modeled using a nonlinear mixed-effects approach. Covariates assessed included body weight and creatinine clearance. Monte Carlo simulations were performed on 1,000 virtual patients to evaluate the probability of target attainment for minimum (Cmin) and maximum (Cmax) plasma concentrations. Results: Among the 50 patients with normal renal function included (MDRD: 115.8 ± 13 mL/min), a one-compartment model was selected, estimating a population volume of distribution (Vpop) of 23.3 L, 70.8 L, and 21.5 L, and a population clearance (Clpop) of 2.4 L/h, 6.5 L/h, and 2.7 L/h for children, adults, and elderly patients, respectively. Relative standard errors were low, indicating good model precision and stability. Simulations demonstrated that optimal doses to achieve target concentrations varied by age group: 50 mg/kg every 24 hours for adults, and 20 mg/kg every 36–48 hours for children and elderly patients. Discussion: These findings suggest that standard dosing regimens are often insufficient to meet efficacy and safety targets. Integrating population pharmacokinetics with therapeutic drug monitoring enables dose individualization, improves treatment efficacy, and reduces the risk of toxicity.

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Keywords: Amikacin, population pharmacokinetics, therapeutic drug monitoring, simulation.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130407

Authors: Fares Aissa BOUDIAF, Saida ABOUBOU, Naoual BOUDOUH, Naoual BEGGARI, Nadia GRAINAT

Affiliations: CHU Batna, Faculty of Medicine, Batna 2 University, LABODOL Laboratory – Algeria.

Abstract

Introduction. Burns are a common and potentially serious condition whose vital prognosis depends on several factors. Mortality remains high, particularly in severe forms. The aim of this study was to describe the severity factors and mortality observed among burn patients hospitalized in our department. Materials and Methods. This prospective, descriptive, and analytical study was conducted in the Burn Unit of Batna University Hospital in 2023. It included patients hospitalized for burns meeting specific criteria related to extent and location. The variables studied encompassed demographic characteristics, causal agent, burn severity, and outcomes (infection and mortality). Assessment relied on standardized tools: the Wallace Rule of Nines, the Lund-Browder chart, and the Baux and UBS scores. Statistical analysis was performed using SPSS (χ² test, p ≤ 0.05), in accordance with ethical standards, including informed consent and patient confidentiality. Results. A total of 233 patients were included. Children aged 1–5 years were the most represented age group. Several severity factors were identified, notably a total burned body surface area (TBSA) exceeding 30%, burn depth, and age extremes (under 5 or over 65 years). The overall mortality rate was 15.9%. Mortality reached 83.3% in flame burns and 64.5% in burns involving more than 50% TBSA. It was also higher in patients with deep burns, and reached 83.3% for a Baux score above 100 and for a UBS score ≥ 150. Furthermore, mortality occurred in 29.4% of infected cases. Conclusion The main factors associated with burn severity and mortality are age, flame burns, burn extent, depth, and infection. This study confirms the importance of early and appropriate management in improving both the vital and functional prognosis of burn patients.

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Keywords: Burns, Severity factors, Mortality, Prognosis, Infection.

Fulltext (PDF)

DOI: 10.48087/BJMS.2026.130406

Authors: Hanifa BENALIKHOUDJA¹, Sofiane GHEMRI^2,3, Nawel  DJOUDI¹

Affiliations: 1- Service de Chirurgie Cardiaque, EHS Dr Maouche Mohand Amokrane, Alger – Algérie. 2- Université des Sciences de la Santé « Moudjahid Dr Youcef El Khatib », Faculté de Médecine d’Alger – Algérie. 3- Service de Cardiologie, EHS Dr Maouche Mohand Amokrane, Alger – Algérie.

Abstract

Objectives: Primary cardiac sarcomas are extremely rare tumors associated with a dismal prognosis. This study aims to report our department’s experience in the surgical management of these tumors and to analyze their short-term outcomes. Methods: We conducted a ten-year retrospective study at the Cardiac Surgery Department of EHS Dr. Maouche. Seven patients with primary cardiac sarcoma were included. All patients underwent preoperative evaluation by echocardiography and magnetic resonance imaging (MRI) prior to surgical resection under cardiopulmonary bypass (CPB). Results: The series comprised various histological subtypes: rhabdomyosarcoma (n=2), angiosarcoma (n=1), liposarcoma (n=1), synovial sarcoma (n=1), fibrosarcoma (n=1), and one rare case of mitral valve sarcoma in a pediatric patient. Tumors were predominantly located in the right and left cardiac chambers with extensive local involvement. Despite macroscopically complete resection in most cases, the postoperative course was marked by a 100% mortality rate within two months, attributable primarily to fulminant local recurrence or metastatic progression. Conclusion: Despite advances in imaging and surgical techniques, primary cardiac sarcomas remain formidable malignancies. Surgical intervention is largely palliative, and the short-term prognosis remains catastrophic, underscoring the urgent need for early multidisciplinary management.

Keywords: Primary cardiac sarcoma, cardiac surgery, histology, prognosis, Algeria.