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DOI: 10.48087/BJMS.2026.130402
Authors: Mohammed Nazim BENNAOUM1,2, Abdelmadjid MEGUEDAD 1,3, Affaf ADDA1,2, Chafika MANOUNI1,3, Mohamed CHEKKAL1,2
Affiliations: 1- Faculté de médecine, Université Oran 1 Ahmed Ben Bella. 2- Service d’hémobiologie et banque de sang, EHU Oran. 3- Service d’hépato-gastro-enterologie, EHU Oran – Algérie.
Abstract
Introduction: Portal vein thrombosis is characterized by the formation of a thrombus within the portal vein. Development of portal vein thrombosis can be secondary to genetic abnormalities, circumstantial factors, iatrogenic or related to other pathologies. Material and methods: In this case study, 67 patients with portal vein thrombosis and 105 healthy individuals as controls were enrolled. We studied the relationship between hemostasis disorders and development of portal vein thrombosis. Results: The mean age of the patients was 44 years with a sex ratio of 0.59. Antithrombin deficiency was found in 37% of patients and 8% of controls. Protein C deficiency was observed in 40% of patients and was absent in controls. Protein S deficiency was present in 27% of patients and 3% of controls. Consequently, a significant statistical relation was found between development of portal vein thrombosis and deficit of physiological coagulation inhibitors. Factor V Leiden and antiphospholipid antibodies were found in 2% and 3% of patients respectively, however, the relation with portal vein thrombosis was not statistically established. Combined deficit of more than one physiological coagulation inhibitor was found in 48% of patients. Conclusion: Deficiency of physiological coagulation inhibitors was a major cause of portal vein thrombosis. However, the constitutional or acquired origin of these defects has not been determined.
Keywords: Portal vein thrombosis, Physiological coagulation inhibitors, Hemostasis.