{"id":712,"date":"2026-03-01T16:59:45","date_gmt":"2026-03-01T16:59:45","guid":{"rendered":"https:\/\/batnajms.net\/?p=712"},"modified":"2026-03-01T17:00:07","modified_gmt":"2026-03-01T17:00:07","slug":"benabed","status":"publish","type":"post","link":"https:\/\/batnajms.net\/index.php\/2026\/03\/01\/benabed\/","title":{"rendered":"Comparison of the impact of amitriptyline and prazepam on sleep quality in patients with pregabalin use disorder"},"content":{"rendered":"\n

Fulltext\u00a0<\/strong><\/a>(PDF)<\/strong><\/h3>\n\n\n\n

DOI<\/strong>: 10.48087\/BJMS.2026.130307<\/p>\n\n\n\n

Authors:<\/strong>\u00a0Fatema Zohra BENABED1,2,3<\/sup>, Ibtissem BOUTRIF1<\/sup>, NH BENZAZOU1<\/sup>,\u00a0Meriem BENABED5<\/sup>,\u00a0Nesrine FEKAR4<\/sup>, Souad GUENDOUZ1,2,3<\/sup>, Mohammed Adil SELKA1,2<\/sup>, Fatma BOUDIA3,6<\/sup>, Hassene BOUCIF1,4<\/sup>, Houari TOUMI3,6<\/sup><\/p>\n\n\n\n

Affiliations:<\/strong>\u00a01- Facult\u00e9 de m\u00e9decine de Tlemcen, Universit\u00e9 de\u00a0Tlemcen \u2013 Alg\u00e9rie. 2- Service de Pharmacie, CHU Tlemcen\u2013 Alg\u00e9rie. 3- Laboratoire de recherche en d\u00e9veloppement pharmaceutique\u00a0\u2013 Alg\u00e9rie. 4- Service de psychiatrie, CHU Tlemcen \u2013 Alg\u00e9rie. 5- Universit\u00e9 des Sciences et de la Technologie d’Oran \u2013 Alg\u00e9rie. 6- Facult\u00e9 de M\u00e9decine d\u2019Oran, Universit\u00e9 d\u2019Oran \u2013 Alg\u00e9rie<\/p>\n\n\n\n

Abstract<\/strong><\/p>\n\n\n\n

Introduction<\/strong> Sleep disturbances are a frequent and disabling symptom of pregabalin withdrawal and represent a major risk factor for relapse. In the absence of specific therapeutic recommendations, various pharmacological strategies are used in clinical practice to improve withdrawal-related comfort. Objective<\/strong> This study aims to compare the effects of amitriptyline and prazepam on sleep quality in patients with pregabalin use disorder. Materials and Methods<\/strong> This was an open-label comparative study including 40 patients managed in an addiction medicine unit. Patients were divided into two groups receiving either amitriptyline or prazepam as part of a medically supervised withdrawal program. Sleep quality was assessed at baseline and at day 30 using the Pittsburgh Sleep Quality Index (PSQI). A comparative statistical analysis was performed, with the type I error rate (\u03b1) set at 5% (p < 0.05). Results<\/strong> A significant improvement in the global PSQI score was observed in both groups after 30 days of treatment. No statistically significant difference was found between the two groups regarding the global PSQI score. However, sleep onset latency was significantly shorter in patients treated with amitriptyline. Conclusion<\/strong> Both amitriptyline and prazepam appear to be effective options for improving sleep quality during pregabalin withdrawal. Amitriptyline may represent a valuable non-benzodiazepine alternative, particularly in patients with predominant sleep-onset insomnia. Larger-scale studies are needed to confirm these findings.<\/p>\n\n\n\n

Keywords:<\/strong>\u00a0Pregabalin, Substance-Related Disorders, Drug Withdrawal Syndrome, Sleep Quality, Pittsburgh Sleep Quality Index.<\/p>\n","protected":false},"excerpt":{"rendered":"

Fulltext\u00a0(PDF) DOI: 10.48087\/BJMS.2026.130307 Authors:\u00a0Fatema Zohra BENABED1,2,3, Ibtissem BOUTRIF1, NH BENZAZOU1,\u00a0Meriem BENABED5,\u00a0Nesrine FEKAR4, Souad GUENDOUZ1,2,3, Mohammed Adil SELKA1,2, Fatma BOUDIA3,6, Hassene BOUCIF1,4, Houari TOUMI3,6 Affiliations:\u00a01- Facult\u00e9 de m\u00e9decine de Tlemcen, Universit\u00e9 de\u00a0Tlemcen \u2013 Alg\u00e9rie. 2- Service de Pharmacie, CHU Tlemcen\u2013 Alg\u00e9rie. 3- Laboratoire de recherche en d\u00e9veloppement pharmaceutique\u00a0\u2013 Alg\u00e9rie. 4- Service de psychiatrie, CHU Tlemcen \u2013 … Continuer la lecture de Comparison of the impact of amitriptyline and prazepam on sleep quality in patients with pregabalin use disorder<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-712","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/posts\/712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/comments?post=712"}],"version-history":[{"count":1,"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/posts\/712\/revisions"}],"predecessor-version":[{"id":713,"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/posts\/712\/revisions\/713"}],"wp:attachment":[{"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/media?parent=712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/categories?post=712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/batnajms.net\/index.php\/wp-json\/wp\/v2\/tags?post=712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}